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In parkinsonian mouse models induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine, compared to wild-type, Nrf2 − / − mice showed greater loss of dopaminergic neurons in the substantia nigra [470–472] and more severe astrogliosis and microgliosis [471, 473]